Central heterochromia involves only the inner ring around the pupil, but some people have what is known as partial heterochromia. Although partial and central heterochromia share some overlap in features, partial heterochromia can be more noticeable because it often appears as a large spot on the iris of one or both eyes (via Healthline). According to Good Housekeeping, Vampire Academy movie star Dominic Sherwood has this rare eye feature, along with actor Bill Pullman, whose surprisingly long list of credits includes: It says it includes fan favorites such as “Casper,'' “Independence Day,'' and “Spaceballs.''
However, the rarest disease is complete heterochromia, which affects only 6 in 10,000 people in the United States, All About Vision reports. Central heterochromia and partial heterochromia only affect part of the iris, while with complete heterochromia, you have two eyes with completely different colors. Actress Mila Kunis has a milder case of this extremely rare eye feature, while baseball pitcher Max Scherzer's full-blown heterochromia iris is obvious as daylight and can cause damage to one eye. The eye is noticeably bright blue, almost gray, and the other eye is a deep dark brown. Actor Dan Aykroyd told the Daily Mail in 2013 that he too was born with complete heterochromia, one green eye and one blue eye.
